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Research activities

  • J-RIDA
  • J-PRECOR (Japan Pretravel Consultation Register)
  • J-GRID (Japan Initiative for Global Research Network on Infectious Disease)

J-RIDA

Information

J-RIDA is a registry of imported infectious diseases in Japan. The National Center for Global Health and Medicine (NCGM) is the main facility, and thirteen medical facilities across the country participate in the registry. The study subject is the patients who visit participating facilities after traveling overseas.

Information

J-PRECOR has been in operation since February 2018 as a pre-travel consultation registry throughout Japan. Our hospital is the main facility, and eight facilities participate in the registry as of March 1, 2019. We are recruiting participating facilities (facilities that offer more than 50 travel consultations a year and can conduct an ethical review at the facilities).

J-GRID

Information

Antimicrobial Resistance (AMR) has become a global issue. The Japanese National Action Plan on AMR specifies international cooperation as one of its mainstays. The DCC and the Research Institute of NCGM have researched healthcare-associated infections (HAIs) and AMR in Vietnam that has a partnership with the NCGM in healthcare technologies, as part of the Japan Initiative for Global Research Network on Infectious Disease (J-GRID). The research started in 2012 as a program under the Ministry of Education, Culture, Sports, Science, and Technology.It was then transferred to J-GRID under the Japan Agency for Medical Research and Development (AMED) in 2015 and is ongoing.

The research aims to present scientific data for controlling AMR, from the perspective of clinical practice, epidemiology, and microbiology. We perform clinical, epidemiological, and microbiological studies concerning AMR across Vietnam, collaborating with local partner hospitals, which are the Bach Mai Hospital in Hanoi and the Cho Ray Hospital in Ho Chi Minh.

About us

Message

Ebola and other hemorrhagic fevers, as well as on malaria and tuberculosis, used to be the internationally threatening infections. Recently, HAIs and AMR have been hot issues as the global economy has been growing, accompanied by healthcare development. 

If these issues were left unattended, a continuity of healthcare itself would be at risk, resulting in the potential loss of many lives. HAIs and AMR have become severe problems in especially Asia, which is calling for urgent countermeasures. 

Under the circumstances, we decided to promote research and development on HAIs and AMR in Vietnam, collaborating with local healthcare professionals. The research project Launched in 2012 and is in progress in Hanoi and Ho Chi Minh.

Partnership between NCGM and Vietnam in Healthcare Technologies

1995 - 2001  Northern Vietnam: Cho Ray Hospital Project
2001 - 2007  Northern Vietnam: Bach Mai Hospital Project
2005       Northern Vietnam: A partnership agreement was concluded between the Bach Mai Hospital and NCGM with the Vietnamese Ministry of Health approval. 
2006       Northern Vietnam: An NCGM-Bach Mai Hospital Healthcare Cooperation Center was established in the Bach Mai Hospital
2007       Central Vietnam: Hue Central Hospital Project
2006 - 2012  Entire Vietnam: Infection prevention and control Program
2014       Southern Vietnam: A partnership agreement was concluded between the Cho Ray Hospital and NCGM with the Vietnamese Ministry of Health approval. 

In progress

  • Vietnamese Ministry of Health (MOH): Advisors dispatched to MOH
  • Southern Vietnam: Local Healthcare Human Resource Ability Upgrading Project
  • Hoa Binh Province: Insurance-covered Healthcare Service Strengthening Project
  • Central Vietnam: Healthcare Service Improvement Project
  • Bach Mai Hospital: MEXT Overseas Base Formation Project
  • Bach Mai Hospital: Local healthcare human resource training abilities

Hospitals as Research Sites

Cho Ray Hospital

Cho Ray Hospital is the largest national hospital in Southern Vietnam, located in Ho Chi Minh City. The hospital was established in 1900, funded by the Vietnamese Ministry of Health. Cho Ray Hospital has approximately 1,900 beds, treats 960,000 inpatients and 1,460,000 outpatients per year, and performs 39,000 surgical operations per year. It is the hub hospital in Ho Chi Minh, the central city in Southern Vietnam, and many patients are delivered to the hospital.

Hospital website: http://choray.vn/

Bach Mai Hospital

Bach Mai Hospital is the largest national hospital in Northern Vietnam, located in Hanoi City. It was established by the French colonial government in 1911 and is now governed by the Vietnam Ministry of Health as the hub hospital in Northern Vietnam. Bach Mai Hospital has approximately 1,900 beds and treats 100,000 inpatients and 900,000 outpatients per year. The hub hospital in Hanoi, the central city in Northern Vietnam, accepts a number of patients. It is an international hospital supported by many partner countries, including Japan, Europe, and the U.S.

Hospital website: http://bachmai.gov.vn/images/stories/en/index.html

Hospitals as Research Sites

Japan staff (DCC)

Norio Ohmagari, Kayoko Hayakawa, Nozomi Takeshita, Satoshi Kutsuna, Maki Nagamatsu, Mitsuhiro Tsuchiya, Masahiro Ishikane

Japan staff (Research Institute)

Teruo Kirikae, Tohru Miyoshi-Akiyama, Tastuya Tada

Vietnamese staff (Coordinator)

Pham Thi Phuong Thuy 

Overview of Research

Project 1: Epidemiological research to clarify the healthcare-associated infections in Vietnam

In medical institutions in Vietnam and other Asian countries where the economy has been developing, healthcare-associated infections have become a substantial social burden. Antimicrobial-resistant bacteria cause such infections with difficulty in treatment and prevention, and their actual status and mechanism of transmission as clinical characteristics and disease burden have yet to be identified. In the research, epidemiological studies, including those of bloodstream infections, are in progress, targeted at the hospital cohorts of healthcare-associated infections in several hospitals in Vietnam. We also started a research that evaluates the effects of the new standard oral care protocol on the decrease of ventilator-associated pneumonia cumulative incidence, comparing before and after the intervention.

Project 2: Research concerning the development of therapeutic options for antimicrobial-resistant bacteria in Vietnam

The shortage in therapeutic options for multi-drug resistant bacteria has been pointed out around the globe, and related research activities are in progress in Europe, the U.S., and other regions. However, very few studies have been conducted in the Asian region and developing countries. Under the circumstances, the research aims at (1) clarifying specific needs for the treatment of multi-drug resistant bacteria in the Asian region, (2) identifying potential medications through microbial studies on multi-drug resistant bacteria, and (3) developing therapeutic options for antimicrobial-resistant bacteria that match the characteristics of Asian people and developing countries.

Project 3: Research for clarifying microbiological epidemiology concerning advanced drug-resistant bacteria in Vietnam

While it has been uncovered that multi-drug resistant bacteria with difficulty in treatment are often isolated from patients in medical institutions in Vietnam and other Asian countries, there is only limited microbiological information concerning multi-drug resistant bacteria. Under the circumstances, the research aims at (1) identifying the types of bacteria and acquiring comprehensive epidemiological information concerning the possession of drug-resistant factors by collecting advanced drug-resistant bacteria every year and determining the complete genome sequence; and (2) based on such epidemiological information, developing simplified test methods using antigen-antibody assays or genetic diagnosis for the types of bacteria and drug-resistant factors with the highest needs.

Publications

2016

  1. Multidrug-resistant ST235 Pseudomonas aeruginosa clinical isolates producing IMP-26 with increased carbapenem hydrolyzing activities in Vietnam.
    Tada T, Nhung PH, Miyoshi-Akiyama T, Shimada K, Tsuchiya M, Phuong DM, Anh NQ, Ohmagari N, Kirikae T.
    Antimicrob Agents Chemother. 2016 Sep 6. pii: AAC.01177-16.
  2. Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam.
    Tada T, Miyoshi-Akiyama T, Shimada K, Nga TT, Thu le TA, Son NT, Ohmagari N, Kirikae T.
    BMC Infect Dis. 2015 Oct 15;15:433. 

2015

  1. IMP-51, a novel IMP-type metallo-β-lactamase with increased doripenem- and meropenem-hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.
    Tada T, Nhung PH, Miyoshi-Akiyama T, Shimada K, Phuong DM, Anh NQ, Ohmagari N, Kirikae T.
    Antimicrob Agents Chemother. 2015 Nov;59(11):7090-3.
  2. Evaluation of the Etest method for detecting colistin susceptibility of multidrug-resistant Gram-negative isolates in Vietnam.
    Nhung PH, Miyoshi-Akiyama T, Phuong DM, Shimada K, Anh NQ, Binh NG, Thanh do V, Ohmagari N, Kirikae T.
    J Infect Chemother. 2015 Aug;21(8):617-9.
  3. The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight.
    Binh NG, Hayakawa K, Co DX, Tuan ND, Anh NH, Thuy NT, Phuong DM, Huong NT, Thuy PT, Chau NQ, Nhung PH, Gam do
    TH, Hai DT, Huong TT, Van Anh L, Takeshita N, Ohmagari N.
    Int J Infect Dis. 2015 Jun;35:18-23. doi: 10.1016/j.ijid.2015.03.020.

2014

  1. Efforts Against Drug-Resistant Bacteria and Bacteremia in Vietnam.
    Takeshita N, Ohmagari N, Kirikae T, Oka S.
    Journal of Disaster Research. 2014; 9 (5), 836 

2013

  1. Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam.
    Tada T, Miyoshi-Akiyama T, Kato Y, Ohmagari N, Takeshita N, Hung NV, Phuong DM, Thu TA, Binh NG, Anh NQ, Nga TT, Truong PH, Xuan PT, Thu le TA, Son NT, Kirikae T.
    BMC Infect Dis. 2013 May 30;13:251.

International Conference

2017

  1. M Ishikane, N Takeshita, Nguyen Gia Binh, Mai Lan Huong, Dao Xuan Co, P Thi Phuong Thuy, Do Van Thanh, Nguyen Quoc Anh, N Ohmagari.
    Epidemiology of healthcare-associated bloodstream infection in an adult intensive care unit: a prospective cohort study of a single tertiary care hospital in Hanoi, Vietnam
    Presented as a poster presentation at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) Vienna, Austria, Apr, 2017.
  2. K Hayakawa, NG Binh, M Nagashima, DX Co, MV Cuong, TT Phuong, ML Huong, PT Thach, PTP Thuy, DV Thanh, ND Tuan, DM Phuong, N Takeshita, N Ohmagari.
    Current epidemiology of ventilator-associated pneumonia in an intensive care unit in Vietnam
    Presented as a poster presentation at ID week, San Diego, USA, 2017.

2015

  1. Binh NG, Hayakawa K, Co DX, Tuan ND, Anh NH, Thuy NT, Phuong DM, Huong NT, Thuy PT, Chau NQ, Nhung PH, Gam do TH, Hai DT, Huong TT, Van Anh L, Takeshita N, Ohmagari N.
    The low incidence of nephrotoxicity associated with colistin use in intensive care unit in Vietnam: Tailored use of colistin in a population with low body weight
    Presented as a poster presentation at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Copenhagen, Denmark, April, 2015.

2014

  1. Nozomi Takeshita.
    Characteristic of Blood Cultures in Large Tertiary Care Hospital in North Vietnam.
    Asia Africa Research Forum 2014, Sendai, Miyagi, Nov, 2014.