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Research activities

  • J-RIDA
  • J-PRECOR
  • J-GRID (Japan Initiative for Global Research Network on Infectious Disease)

J-RIDA

Information

It is an imported infectious disease registry for all of Japan, and 13 facilities across the country are participating with this hospital as the main facility. This study is for patients who visited a participating facility after returning from overseas.

J-PRECOR

Information

It has been in operation since February 2018 as a pre-travel consultation registry throughout Japan. Our hospital is the main facility, and as of March 1, 2019, eight facilities are participating. We are recruiting participating facilities (a facility that has received more than 50 travel consultations a year and can conduct an ethical review at their own facility).

J-GRID

Information

Antimicrobial Resistance (AMR) has become a global issue. The Japanese National Action Plan on AMR also specifies international cooperation as one of its mainstays. Since 2012, the Disease Control and Prevention Center (DCC) and Research Institute National Center for Global Health and Medicine (NCGM), has promoted research concerning healthcare-associated infections (HAIs) and AMR in Vietnam, which has a partnership with NCGM in healthcare technologies, as part of the Japan Initiative for Global Research Network on Infectious Disease (J-GRID).

The present research was started in 2012 as a program under the Ministry of Education, Culture, Sports, Science and Technology, which was then transferred to J-GRID under the Japan Agency for Medical Research and Development (AMED) in 2015 for continuous research.

Toward the goal of presenting scientific data for controlling AMR from the perspectives of clinical practice, epidemiology and microbiology, this program performs clinical, epidemiological and microbiological studies concerning AMR across Vietnam, in collaboration with local partner hospitals. The key local partner hospitals are the Bach Mai Hospital in Hanoi and the Cho Ray Hospital in Ho Chi Minh

About us

Message

The issues of internationally threatening infections used to be focused on Ebola and other hemorrhagic fevers, as well as on malaria and tuberculosis. Recently, as the economy has been developing around the world, accompanied by the global development of healthcare, HAIs and AMR have become major issues.

If these issues were left unattended, the continuity of healthcare itself might be threatened, resulting in the potential loss of many lives. Among other regions, HAIs and AMR have become serious problems in Asia, calling for urgent countermeasures.

Under these circumstances, we decided to promote research and development concerning HAIs and AMR in Vietnam, in collaboration with local healthcare professionals. This project was started in 2012, and research activities are in progress in Hanoi and in Ho Chi Minh.

Partnership between NCGM and Vietnam in Healthcare Technologies

1995 - 2001  Northern Vietnam; Cho Ray Hospital Project
2001 - 2007  Northern Vietnam; Bach Mai Hospital Project
2005       Northern Vietnam; With approval of the Vietnamese Ministry of Health, a partnership agreement was concluded between the Bach Mai Hospital and NCGM
2006       Northern Vietnam; An NCGM-Bach Mai Hospital Healthcare Cooperation Center was established in the Bach Mai Hospital
2007       Central Vietnam; Hue Central Hospital Project
2006 - 2012  Entire Vietnam; Infection prevention and control Program
2014       Southern Vietnam; With approval of the Vietnamese Ministry of Health, a partnership agreement was concluded between the Cho Ray Hospital and NCGM

In progress

  • Vietnamese Ministry of Health (MOH); Advisors dispatched to MOH
  • Southern Vietnam; Local Healthcare Human Resource Ability Upgrading Project
  • Hoa Binh Province; Insurance-covered Healthcare Service Strengthening Project
  • Central Vietnam; Healthcare Service Improvement Project
  • Bach Mai Hospital; MEXT Overseas Base Formation Project
  • Bach Mai Hospital; Local healthcare human resource training abilities

Hospitals as Research Sites

Cho Ray Hospital

The Cho Ray Hospital is the largest national hospital in Southern Vietnam, located in Ho Chi Minh City. The hospital was established in 1900, funded by the Vietnamese Ministry of Health. The Cho Ray Hospital has approx. 1,900 beds, treats approx. 960,000 inpatients and approx. 1,460,000 outpatients per year, and performs 39,000 surgical operations per year. It is the hub hospital in Ho Chi Minh, the central city in Southern Vietnam, and a number of patients are delivered to this hospital.

Hospital website: http://choray.vn:81/

Bach Mai Hospital

The Bach Mai Hospital is the largest national hospital in Northern Vietnam, located in Hanoi City. It was established by the French colonial government in 1911, and is now governed by the Vietnam Ministry of Health as the hub hospital in Northern Vietnam. The Bach Mai Hospital has approx. 1,900 beds, and treats approx. 100,000 inpatients and approx. 900,000 outpatients per year. It is the hub hospital in Hanoi, the central city in Northern Vietnam, and a number of patients are delivered to this hospital. It is an international hospital with many supporting and partner countries including Japan, Europe and the U.S.

Hospital website: http://bachmai.gov.vn/images/stories/en/index.html

Hospitals as Research Sites

Japan staff (DCC)

Norio Ohmagari, Kayoko Hayakawa, Nozomi Takeshita, Satoshi Kutsuna, Maki Nagamatsu, Mitsuhiro Tsuchiya, Masahiro Ishikane

Japan staff (Research Institute)

Teruo Kirikae, Tohru Miyoshi-Akiyama, Tastuya Tada

Vietnamese staff (Coordinator)

Pham Thi Phuong Thuy 

Overview of Research

Project 1: Epidemiological research to clarify the healthcare-associated infections in Vietnam

In medical institutions in Vietnam and other Asian countries where the economy has been developing, healthcare-associated infections have become substantial social burden. Such infections are caused by antimicrobial resistant bacteria with difficulty in treatment and prevention, and their actual status and mechanism of transmission have yet to be identified as clinical characteristics and disease burden. In this research, epidemiological studies are in progress targeted at the hospital cohorts of healthcare-associated infections in several key hospitals in Vietnam, including those of blood stream infections. Furthermore, the research to evaluate the effects of the new standard oral care protocol in terms of the ventilator associated pneumonia cumulative incidence difference comparing before and after the intervention is in progress.

Project 2: Research concerning the development of therapeutic options for antimicrobial-resistant bacteria in Vietnam

At present, shortage in therapeutic options for multi-drug resistant bacteria has been pointed out around the globe, and related research activities are in progress in Europe, the U.S. and other regions. However, only a very few studies have been conducted in the Asian region and developing countries. Under these circumstances, this research is aimed at (1) clarifying specific needs for the treatment of multi-drug resistant bacteria in the Asian region, (2) identifying potential medications through microbial studies concerning multi-drug resistant bacteria, and (3) developing therapeutic options for antimicrobial-resistant bacteria that match the characteristics of Asian people and of developing countries.

Project 3: Research for clarifying microbiological epidemiology concerning advanced drug-resistant bacteria in Vietnam

While it has been uncovered that multi-drug resistant bacteria with difficulty in treatment are often isolated in medical institutions in Vietnam and other Asian countries, there is only limited microbiological information concerning multi-drug resistant bacteria. Under these circumstances, this research is aimed at (1) collecting advanced drug-resistant bacteria every year, and determining the complete genome sequence thereof, thereby identifying the types of bacteria and acquiring comprehensive epidemiological information concerning the possession of drug resistant factors; and (2) based on such epidemiological information, developing simplified test methods using antigen-antibody assays or genetic diagnosis for the types of bacteria and drug resistant factors with the highest needs.

Publications

2016

  1. Multidrug-resistant ST235 Pseudomonas aeruginosa clinical isolates producing IMP-26 with increased carbapenem hydrolyzing activities in Vietnam.
    Tada T, Nhung PH, Miyoshi-Akiyama T, Shimada K, Tsuchiya M, Phuong DM, Anh NQ, Ohmagari N, Kirikae T.
    Antimicrob Agents Chemother. 2016 Sep 6. pii: AAC.01177-16.
  2. Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam.
    Tada T, Miyoshi-Akiyama T, Shimada K, Nga TT, Thu le TA, Son NT, Ohmagari N, Kirikae T.
    BMC Infect Dis. 2015 Oct 15;15:433. 

2015

  1. IMP-51, a novel IMP-type metallo-β-lactamase with increased doripenem- and meropenem-hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.
    Tada T, Nhung PH, Miyoshi-Akiyama T, Shimada K, Phuong DM, Anh NQ, Ohmagari N, Kirikae T.
    Antimicrob Agents Chemother. 2015 Nov;59(11):7090-3.
  2. Evaluation of the Etest method for detecting colistin susceptibility of multidrug-resistant Gram-negative isolates in Vietnam.
    Nhung PH, Miyoshi-Akiyama T, Phuong DM, Shimada K, Anh NQ, Binh NG, Thanh do V, Ohmagari N, Kirikae T.
    J Infect Chemother. 2015 Aug;21(8):617-9.
  3. The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight.
    Binh NG, Hayakawa K, Co DX, Tuan ND, Anh NH, Thuy NT, Phuong DM, Huong NT, Thuy PT, Chau NQ, Nhung PH, Gam do
    TH, Hai DT, Huong TT, Van Anh L, Takeshita N, Ohmagari N.
    Int J Infect Dis. 2015 Jun;35:18-23. doi: 10.1016/j.ijid.2015.03.020.

2014

  1. Efforts Against Drug-Resistant Bacteria and Bacteremia in Vietnam.
    Takeshita N, Ohmagari N, Kirikae T, Oka S.
    Journal of Disaster Research. 2014; 9 (5), 836 

2013

  1. Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam.
    Tada T, Miyoshi-Akiyama T, Kato Y, Ohmagari N, Takeshita N, Hung NV, Phuong DM, Thu TA, Binh NG, Anh NQ, Nga TT, Truong PH, Xuan PT, Thu le TA, Son NT, Kirikae T.
    BMC Infect Dis. 2013 May 30;13:251.

International Conference

2017

  1. M Ishikane, N Takeshita, Nguyen Gia Binh, Mai Lan Huong, Dao Xuan Co, P Thi Phuong Thuy, Do Van Thanh, Nguyen Quoc Anh, N Ohmagari.
    Epidemiology of healthcare-associated bloodstream infection in an adult intensive care unit: a prospective cohort study of a single tertiary care hospital in Hanoi, Vietnam
    Presented as a poster presentation at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) Vienna, Austria, Apr, 2017.
  2. K Hayakawa, NG Binh, M Nagashima, DX Co, MV Cuong, TT Phuong, ML Huong, PT Thach, PTP Thuy, DV Thanh, ND Tuan, DM Phuong, N Takeshita, N Ohmagari.
    Current epidemiology of ventilator-associated pneumonia in an intensive care unit in Vietnam
    Presented as a poster presentation at ID week, San Diego, USA, 2017.

2015

  1. Binh NG, Hayakawa K, Co DX, Tuan ND, Anh NH, Thuy NT, Phuong DM, Huong NT, Thuy PT, Chau NQ, Nhung PH, Gam do TH, Hai DT, Huong TT, Van Anh L, Takeshita N, Ohmagari N.
    The low incidence of nephrotoxicity associated with colistin use in intensive care unit in Vietnam: Tailored use of colistin in a population with low body weight
    Presented as a poster presentation at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Copenhagen, Denmark, April, 2015.

2014

  1. Nozomi Takeshita.
    Characteristic of Blood Cultures in Large Tertiary Care Hospital in North Vietnam.
    Asia Africa Research Forum 2014, Sendai, Miyagi, Nov, 2014.